We are pleased to highlight a significant research publication from Dr. Catherina Pinnaro, a former T32 trainee and now faculty member of the Fraternal Order of Eagles Diabetes Research Center. Dr. Pinnaro’s latest study explores the role of the X-chromosome in modifying diabetes risk, with a particular focus on individuals with Turner syndrome. Her findings reveal that individuals with Turner syndrome who inherit a single X-chromosome from their mother are at a higher risk of elevated blood sugar levels compared to those who inherit their X-chromosome from their father. These results, recently accepted for publication in Hormone Research in Pediatrics, have broader implications for understanding diabetes risk in the general population. Given that males always inherit their X-chromosome from their mother, and females inherit one X from each parent, the study raises important considerations about how parental origin of X-chromosomes may influence metabolic health. Dr. Andrew Norris, Co-Director of the FOEDRC, contributed to this research, further emphasizing our center’s commitment to advancing knowledge in diabetes and metabolic disease. We look forward to the impact this work will have on future studies and potential clinical applications.